Trombophilia 6 Mutation Panel, Trombophilia MSQ 2.1

For in vitro diagnostic use. Intended for professional use only.

Thrombophilia refers to a condition characterized by an excessive formation of blood clots or a tendency to clot more than normal.

This condition can increase the risk of serious health problems by elevating the likelihood of blood clot formation in the body. Thrombophilia can arise from genetic factors as well as various other causes.

Important Genetic Mutations:

PAI-1 (4G/5G Promoter): This mutation represents a change in the plasminogen activator inhibitor-1 (PAI-1) gene. PAI-1 is a protein that regulates blood clot formation.
Factor XIII (V34L): Factor XIII regulates the formation of fibrinolysis, a protein that ensures the stability of blood clots.
Factor II Prothrombin (G20210A): This mutation indicates a change in the prothrombin protein that controls blood clotting.
Factor V (G1691A-R506Q): This mutation affects the activity of factor V protein and may contribute to blood clot formation.
MTHFR (C677T and A1298C): These genetic variations can impact the function of methylenetetrahydrofolate reductase (MTHFR) enzyme and are related to folate metabolism.

FEATURES

Fast and Easy to Use with Multiplex Mini Sequencing PCR Technology: Thrombophilia 6 Mutation Panel, Thrombophilia MSQ 2.1 Kit, is easily and quickly utilized through Multiplex Mini Sequencing PCR technology. This technology enables the rapid detection of multiple mutations simultaneously, optimizing laboratory processes.

High Sensitivity: The employed technology has the capability to detect even low mutation percentages. This contributes to reliably identifying genetic mutations, facilitating accurate diagnoses.

Gene Mutations: It detects mutations in human PAI-1 (4G/5G Promoter), Factor XIII (V34L), Factor II Prothrombin (G20210A), Factor V (G1691A-R506Q), MTHFR (C677T and A1298C) genes. These genes encompass significant genetic factors influencing the risk of thrombophilia.

Thrombophilia 6 Mutations Panel, Thrombophilia MSQ 2.1 Kit, assists in the rapid and precise analysis of the genetic profile of thrombophilia patients, guiding them towards appropriate treatment. With its high sensitivity and user-friendly design, it optimizes your laboratory work and aids in obtaining accurate results. Taking this crucial step with this kit can enhance the quality of life for thrombophilia patients.

DATA INTERPRETATION

Figure 1: ABI 3500 Genetic Analyzer Image of Thrombophilia 6 Mutations Panel, Thrombophilia MSQ 2.1 Kit's WT and Mutations.

ORDER INFORMATION

CATALOG NO	MSQHLKSTP02-25: Thrombophilia 6 Mutations Panel, Thrombophilia MSQ 2.1 (25 Tests)
	MSQHLKSTP02-50: Thrombophilia 6 Mutations Panel, Thrombophilia MSQ 2.1 (50 Tests)
	MSQHLKSTP02-100 Thrombophilia 6 Mutations Panel, Thrombophilia MSQ 2.1 (100 Tests)
SAMPLE TYPE	Whole Blood in EDTA Tube
TEST CONTENT	TP6 Primer Mix, TP6 MSQ Mix, PCR Master Mix, DMSO, Taq DNA Polymerase, ddH2O, EXO I, SAP, SNaPshot Mix
TARGET GENE and LOCI	PAI-1 (4G/5G Promoter), Factor XIII (V34L), Factor II Prothrombin (G20210A), Factor V (G1691A-R506Q), MTHFR (C677T and A1298C)
STORAGE CONDITIONS and SHELF LIFE	Stored at -20 °C and in the dark. Shelf life is 12 months.
COMPATIBLE DEVICES	All PCR Devices, ABI 3130, 3500, and other genetic analyzers